2-Deoxyuridine-5-triphosphoric acid disodium salt
2'-deoxyuridine 5'-monophosphate*disodium sigma G
CAS: 42155-08-8
Molecular Formula: C9H11N2Na2O8P
2-Deoxyuridine-5-triphosphoric acid disodium salt - Names and Identifiers
| Name | 2'-deoxyuridine 5'-monophosphate*disodium sigma G |
| Synonyms | dump dUMP.Na2 dUTP-Na2 2'-deoxy-5'-uridylic acid 2'-Deoxy-5'-uridylic acid disodium salt 5'-Uridylic acid, 2'-deoxy-, disodium salt 2'-Deoxyuridine-5'-monophosphate,sodiumsalt 2'-Deoxyuridine-5'-monophosphate,disodium salt 2'-Deoxyuridine 5'-monophosphate disodium salt 2'-Deoxyuridine 5'-Monophosphate Disodium Salt 2'-deoxyuridine 5'-monophosphate*disodium sigma G 2-Deoxyuridine-5-triphosphoric acid disodium salt 2'-DEOXYURIDINE 5'-MONOPHOSPHATEDISODIUM SIGMA GRA 2''-Deoxyuridine-5''-monophosphoric acid disodium salt 2''-DEOXYURIDINE 5''-MONOPHOSPHATE DISODIUM SALT (DUMP-NA2) 2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-5-O-phosphonopentofuranosyl)-, monosodium salt |
| CAS | 42155-08-8 |
| EINECS | 255-687-1 |
| InChI | InChI=1/C9H13N2O8P.Na/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17;/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17) |
2-Deoxyuridine-5-triphosphoric acid disodium salt - Physico-chemical Properties
| Molecular Formula | C9H11N2Na2O8P |
| Molar Mass | 352.15 |
| Water Solubility | Soluble in water. |
| Appearance | Powder |
| Color | White to Off-white |
| Storage Condition | -20°C |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00065282 |
2-Deoxyuridine-5-triphosphoric acid disodium salt - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29349990 |
2-Deoxyuridine-5-triphosphoric acid disodium salt - Reference Information
| preparation | 2 '-iodouridine (5g,14.1mmol),10% wet palladium carbon (0.1g) and triethylamine (1.8g,18mmol), added to ethanol (100mL), stirred at room temperature for 30min, replaced hydrogen, and maintained the hydrogen pressure in the reaction bottle at 1atm, after stirring at room temperature for 2 hours, TLC showed that the raw materials reacted completely. 2g of diatomite was added. After stirring for 10min, palladium and carbon were removed by suction filtration, the filtrate was concentrated to obtain oil, phosphoric acid (50mL) was added, heated and dissolved, white solid was precipitated after cooling, filtered and washed until almost colorless. After the filter cake was dried, crude product 2'-deoxyuridine -5 '-disodium monophosphate salt was obtained. After recrystallization, filtration and drying were carried out to obtain 2.96g, the yield was 92% and the HPLC purity was 98%. |
| Biological activity | 2-deoxyuridine -5 '-disodium monophosphate (dUMP) is the substrate of thymidylate synthase and can be converted into deoxythymidine monophosphate (dTMP). In the methylation step, the inhibitory effect of dUMP on dTMP is the key to control the growth of bacteria and eukaryotic cells. |
Last Update：2024-04-09 20:45:29
Supplier List
Spot supply
Product Name: Diquafosol Impurity 30 Visit Supplier Webpage Request for quotationCAS: 42155-08-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: dUMP,2Na Visit Supplier Webpage Request for quotationCAS: 42155-08-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Diquafosol Impurity 30 Visit Supplier Webpage Request for quotationCAS: 42155-08-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: dUMP,2Na Visit Supplier Webpage Request for quotationCAS: 42155-08-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History